IL-4 Receptor a Subunit Deficiency Alleviates Murine Intestinal Inflammation In Vivo through the Enhancement of Intestinal Mucosal Barrier Function

GSE157754

Mus musculus

3 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

In the present study we investigate the role of IL-4 receptor a subunit in intestinal inflammation using DSS-induced colitis model. Our finding suggest that IL-4Ra deficiency enhances intestinal mucosal barrier function through the upregulation of NOX1-dependent ROS production, thereby suppressing the development of intestinal inflammation.

PubMed ID

33192516

Publication Title

Interleukin-4 Receptor α Subunit Deficiency Alleviates Murine Intestinal Inflammation In Vivo Through the Enhancement of Intestinal Mucosal Barrier Function.

Total Samples

Submitter’s Institution

University of Toyama

Authors

Hertati A, Hayashi S, Ogawa Y, Yamamoto T, Kadowaki M

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-157754

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