MUTYH is associated with hepatocarcinogenesis in a NASH model mouse

Mice with MUTYH-null allele (Mutyh+/-, Mutyh-/-) were fed a high-fat/high-cholesterol (HFHC) diet or HFHC + high iron diet. The incidence of liver tumors and histological features of the liver were compared.

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Sakamoto H, Miyanishi K, Tanaka S, Ito R, Hamaguchi K, Sakurada A, Sato M, Kubo T, Osuga T, Murase K, Takada K, Nakabeppu Y, Kobune M, Kato J