Differential gene expression in RA synovial biopsies from responders versus non-responders to adalimumab therapy

GSE15602

Homo sapiens

9 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

TNF antagonists are routinely used in severe rheumatoid arthritis (RA) patients who failed conventional DMARD therapy. According to large clinical trials, the three available drugs (adalimumab, infliximab and etanercept) display similar effects in terms of efficacy, tolerability and side effects. These studies also indicate that about 25% of RA patients treated with TNF-antagonists do not display any significant clinical improvement.

PubMed ID

19389237

Publication Title

Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis.

Total Samples

Submitter’s Institution

Universit catholique de Louvain

Authors

Badot V, Galant C, Nzeusseu Toukap A, Theate I, Maudoux AL, Van den Eynde BJ, Durez P, Houssiau FA, Lauwerys BR

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-15602

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