Comparative transcriptomic profiling of human colon cells (CCD-18Co) exposed to an orange extract rich in flavanones

We used microarrays to investigate gene expression changes in human colon normal fibroblasts exposed to a bitter orange extract enriched in flavanones (and previously subjected to in vitro gastro-duodenal digestion) to determine possible modulatory beneficial effects induced by these plant-derived compounds on the colon cells.

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Giménez-Bastida JA, Martínez-Florensa M, Espín JC, Tomás-Barberán FA, García-Conesa MT