Gene expression profiling of mouse uterine stromal cells isolated on day 5 of pregnancy

Our study revealed that hypoxia inducible factor 2 alpha, Hif2 alpha, is a downstream target of estrogen signaling in mouse uterine stroma at the time of implantation. Further, conditional deletion of Hif2 alpha in mouse uterus leads to infertility due to impaired epithelial remodeling at the time of implantation.

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Bhurke A, Kannan A, Neff A, Ma Q, Laws MJ, Taylor RN, Bagchi MK, Bagchi IC