Gene expression data of cSHMT mutant, heterozygous, and wild-type mouse colons

GSE14645

Mus musculus

9 Downloadable Samples

Affymetrix Mouse Genome 430A 2.0 Array (mouse430a2)

Submitter Supplied Information

Description

Folate-mediated one-carbon metabolism is required for purine, thymidylate, and S-adenosylmethionine synthesis. Impairments in folate metabolism diminish cellular methylation potential and genome stability. Cytoplasmic serine hydroxymethyl transferase (cSHMT) regulates partitioning between thymidylate and SAM biosynthesis. These experiments were designed to determine if mutations in cSHMT led to alterations in gene expression.

PubMed ID

21406397

Publication Title

Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.

Total Samples

Submitter’s Institution

Cornell University

Authors

Macfarlane AJ, Perry CA, McEntee MF, Lin DM, Stover PJ

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-14645

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