Sexual dimorphism in the immune system becomes evident in the perinatal period in the four core genotypes mouse

We conclude an existence of a previously unrecognized role for estradiol in the regulation of cell development in the neonatal thymus and an organizational role for perinatal testosterone in the development of immune sexual dimorphism

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Ghosh MK, Chen KE, Dill-Garlow R, Ma LJ, Yonezawa T, Itoh Y, Rivera L, Radecki KC, Wu QP, Arnold AP, Muller HK, Walker AM