Therapeutic efficacy of human umbilical cord blood-derived mesenchymal stem cells in myocardial repair after infarction

Human UCB-MSCs showed donor-specific variation of therapeutic efficacy in improving LV systolic function, reducing infarct area, and preserving wall thickness after MI, even though there were no significant differences in MSC phenotypes. UCB-MSCs (M02) which showed better efficacy had better paracrine activity and unique gene expression profile than others.

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Lee EJ, Choi EK, Kang SK, Kim GH, Park JY, Kang HJ, Lee SW, Kim KH, Kwon JS, Lee KH, Ahn Y, Lee HJ, Cho HJ, Choi SJ, Oh WI, Park YB, Kim HS