Expression data from Pseudomonas aeruginosa exposed to a low concentration of Azithromycin

GSE12738

Pseudomonas aeruginosa

5 Downloadable Samples

Affymetrix Pseudomonas aeruginosa Array (paeg1a)

Submitter Supplied Information

Description

Low-dose macrolides are effective therapy in patients with chronic lung infections, but the mechanisms of action are unclear. We compared global gene expression profiles between P.aeruginosa with and without low-dose Azithromycin (AZM) to study why the low-dose macrolide therapy is effective for cystic fibrosis and diffuse panbronchiolitis.

PubMed ID

19393329

Publication Title

A low concentration of azithromycin inhibits the mRNA expression of N-acyl homoserine lactone synthesis enzymes, upstream of lasI or rhlI, in Pseudomonas aeruginosa.

Total Samples

Submitter’s Institution

Dainippon Sumitomo Pharma Co., Ltd.

Authors

Kai T, Tateda K, Kimura S, Ishii Y, Ito H, Yoshida H, Kimura T, Yamaguchi K

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-12738

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