Changes in cardiac transcription profiles following on-pump coronary artery bypass grafting

To investigate changes in cardiac transcription profiles caused by on-pump cardiac surgery, we collected myocardial samples, prior and after grafting, from patients undergoing on-pump coronary artery bypass grafting with cardiopulmonary bypass and cardiac arrest. The transcriptional profile of the mRNA in these samples was measured with gene array technology. Changes in transcriptional profiles can be correlated with the stress response of heart to surgery, cardiopulmonary bypass and cardiac arrest.

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Ghorbel MT, Cherif M, Mokhtari A, Bruno VD, Caputo M, Angelini GD