Anti-Nogo-A antibody treatment of Rat Hippocampal Slice Cultures

GSE12483

Rattus norvegicus

12 Downloadable Samples

Affymetrix Rat Genome 230 2.0 Array (rat2302)

Submitter Supplied Information

Description

The neurite outgrowth inhibitory myelin protein Nogo-A has been well studied in the context of central nervous system (CNS) injury and disease. We studied the effects of the application of neutralizing anti-Nogo-A antibodies (11C7 and 7B12) in intact CNS tissue in vitro using rat organotypic hippocampal slice cultures. This study had the purpose of elucidating the role of Nogo-A in the adult intact CNS and determining the consequences of its neutralization through antibody application.

PubMed ID

18973596

Publication Title

Neutralization of the membrane protein Nogo-A enhances growth and reactive sprouting in established organotypic hippocampal slice cultures.

Total Samples

Submitter’s Institution

Brain Research Institute - UZH/ETHZ - Zurich

Authors

Craveiro LM, Hakkoum D, Weinmann O, Montani L, Stoppini L, Schwab ME

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-12483

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