Topoisomerase II inhibition involves characteristic chromosomal expression patterns: Doxorubicin study

GSE11940

Homo sapiens

10 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

A variety of important anticancer drugs kill cells by increasing cellular levels of topoisomerase II-DNA cleavage complex. The anthracycline anticancer drug doxorubicin forms a stable ternary complex with DNA and topoisomerase IIa, thereby inhibiting the normal function of the enzyme.

PubMed ID

18611269

Publication Title

Topoisomerase II inhibition involves characteristic chromosomal expression patterns.

Total Samples

Submitter’s Institution

Fraunhofer Institut

Authors

Reymann S, Borlak J

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-11940

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