Global Gene Expression of H9 hESC with different passage numbers

GSE119386

Homo sapiens

4 Downloadable Samples

Illumina HumanHT-12 V4.0 expression beadchip

Submitter Supplied Information

Description

Transcriptome profile was obtained from a set of human embryonic stem cell (hESCs) line (WA09: H9) with different passage numbers (P1: 40s, P2: 100s, P3: 200s, P4: 300s passage). Culture adaptation occurs in hESCs during repeated in vitro culture to acquire survival advantage to be highly resistant to various stresses. In special, difference in gene expression profile of cell death or apoptotic gene signature was evident between P1/P2 and P3/P4 hESCs.

PubMed ID

30293852

Publication Title

Selective Elimination of Culture-Adapted Human Embryonic Stem Cells with BH3 Mimetics.

Total Samples

Submitter’s Institution

Seoul National University

Authors

Cho SJ, Kim KT, Jeong HC, Park JC, Kwon OS, Song YH, Shin JG, Kang S, Kim W, Shin HD, Lee MO, Moon SH, Cha HJ

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-119386

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