Lung transcriptome from M. avium infected WT, IFNg-/- and IRF1-/- mice

Mycobacterium avium infection in mice induces granuloma necrosis in the lung which is dependent on IFNg. IRF1 is a transcription factor activated by IFNg signaling. The effect of IFNg and IRF1 on immunopathology and transcriptional changes in the lung were analysed using gene-deficient mice.

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Aly S, Mages J, Reiling N, Kalinke U, Decker T, Lang R, Ehlers S