Gene expression profiles of tumor-induced pTregs and anergic tumor-specific CD4+ T cells

Up to now the role of tumor-specific pTregs and anergic cells during tumor development is not fully understood. Here we used a genetically-induced tumor expressing a MHC-II restricted DBY model antigen to characterize the tumor-induced pTregs and anergic cells that arise early during tumor development.

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Alonso R, Flament H, Lemoine S, Sedlik C, Bottasso E, Péguillet I, Prémel V, Denizeau J, Salou M, Darbois A, Núñez NG, Salomon B, Gross D, Piaggio E, Lantz O