Gene expression changes induced by the BET inhibitor GSK525762 and/or the MEK inhibitor trametinib in cancer cell lines.

GSE112282

Homo sapiens

45 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

Transcriptional changes were analyzed in two colorectal cancer, two pancreatic cancer, and one small cell lung cancer cell line following treatment with the BET inhibitor GSK525762 and/or the MEK inhibitor trametinib using Affymetrix Human Genome U133 Plus 2.0 Arrays.

PubMed ID

29674704

Publication Title

MEK inhibitors overcome resistance to BET inhibition across a number of solid and hematologic cancers.

Total Samples

Submitter’s Institution

GlaxoSmithKline LLC

Authors

Wyce A, Matteo JJ, Foley SW, Felitsky DJ, Rajapurkar SR, Zhang XP, Musso MC, Korenchuk S, Karpinich NO, Keenan KM, Stern M, Mathew LK, McHugh CF, McCabe MT, Tummino PJ, Kruger RG, Carpenter C, Barbash O

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-112282

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