Distinct constitutive and pathogen-induced transcriptional programs in dendritic cells derived from CD16- versus CD16+ monocytes

GSE111474

Homo sapiens

14 Downloadable Samples

Affymetrix Human Gene 2.0 ST Array (hugene20st)

Submitter Supplied Information

Description

Classical CD16- versus intermediate/non-classical CD16+ monocytes differ in their homing potential and immunological functions; but whether they differentiate into dendritic cells (DC) with distinct contributions to immunity against bacterial/viral pathogens remains poorly investigated. Here, we employed a systems biology approach to identify differences between CD16+ and CD16- monocyte-derived DC (MDDC) with potential clinical relevance

PubMed ID

30381402

Publication Title

CD16+ monocytes give rise to CD103+RALDH2+TCF4+ dendritic cells with unique transcriptional and immunological features.

Total Samples

Submitter’s Institution

Universit de Montral

Authors

Wacleche VS, Cattin A, Goulet JP, Gauchat D, Gosselin A, Cleret-Buhot A, Zhang Y, Tremblay CL, Routy JP, Ancuta P

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-111474

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