Gene array analysis of WT and SKO macrophages following engulfment of irradiated HEK 293 cells with/without double-stranded DNA

The ability of dying cells to activate antigen presenting cells (APCs) is carefully controlled to avoid unwarranted inflammatory responses. Here we show that engulfed cells only containing cytosolic dsDNA species (viral or synthetic) or cyclic di-nucleotides (CDNs) are able to stimulate APCs, via extrinsic STING-signaling.

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Ahn J, Xia T, Rabasa Capote A, Betancourt D, Barber GN