Lungs from mice infected with S. pneumoniae and treated with Nemiralisib

GSE109941

Mus musculus

48 Downloadable Samples

Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description

Bacterial infections cause exaserbations in COPD. Study conducted to asses the effect of Nemiralisib, a PI3Kdelta inhibitor, on S. pneumoniae infected mice

PubMed ID

30093657

Publication Title

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner.

Total Samples

Submitter’s Institution

GSK

Authors

Stark AK, Chandra A, Chakraborty K, Alam R, Carbonaro V, Clark J, Sriskantharajah S, Bradley G, Richter AG, Banham-Hall E, Clatworthy MR, Nejentsev S, Hamblin JN, Hessel EM, Condliffe AM, Okkenhaug K

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-109941

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