Predictive computational obesity risk framework through integration of gene expression profiles and genetic risk score.

We aimed to predict obesity risk with genetic data, specifically, obesity-associated gene expression profiles. Genetic risk score was computed. The genetic risk score was significantly correlated with BMI when an optimization algorithm was used. Linear regression and built support vector machine models predicted obesity risk using gene expression profiles and the genetic risk score with a new mathematical method.

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Joseph PV, Wang Y, Fourie NH, Henderson WA