NUP98/HHEX a new oncogenic fusion with acute myeloid leukemia

GSE10909

Mus musculus

9 Downloadable Samples

Affymetrix Mouse Genome 430A 2.0 Array (mouse430a2)

Submitter Supplied Information

Description

We have cloned and characterized a fusion gene NUP98/HHEX1 resulting from t(7;10) from a patient with acute myeloid leukemia (AML). As NUP98/HHEX acts as an aberrant transcriptional activator, putative targets were searched upon transient expression of the fusion in primary murine bone marrow cells.

PubMed ID

18388181

Publication Title

Leukemogenic mechanisms and targets of a NUP98/HHEX fusion in acute myeloid leukemia.

Total Samples

Submitter’s Institution

Universityhospital of Basel

Authors

Jankovic D, Gorello P, Liu T, Ehret S, La Starza R, Desjobert C, Baty F, Brutsche M, Jayaraman PS, Santoro A, Mecucci C, Schwaller J

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-10909

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