Transcriptome analysis of HTLV-1 Tax-transformed T cell line Tesi in absence and presence of Tax

GSE10508

Homo sapiens

3 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

The Tesi system allows analysis of HTLV-1 Tax's impact on the transcriptome of a human CD4+ T-cell which is not derived from leukemia but directly from normal human lymphocytes. By comparing cells with and without Tax, one can specifically filter for celluar genes that are either activated or repressed in the presence of Tax.

PubMed ID

18276843

Publication Title

Strong induction of 4-1BB, a growth and survival promoting costimulatory receptor, in HTLV-1-infected cultured and patients' T cells by the viral Tax oncoprotein.

Total Samples

Submitter’s Institution

Universitt Erlangen Nrnberg

Authors

Pichler K, Kattan T, Gentzsch J, Kress AK, Taylor GP, Bangham CR, Grassmann R

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-10508

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