Long noncoding RNA NKX2-1-AS1 inhibits cell migration and regulates cell-adhesion independent of NKX2-1 in human lung carcinoma cells

GSE104691

Homo sapiens

3 Downloadable Samples

Affymetrix Human Gene 2.0 ST Array (hugene20st)

Submitter Supplied Information

Description

The long noncoding RNA NKX2-1-AS1 is highly expressed in primary lung adenocarcinomas compared to squamous carcinomas, similar to its adjacent protein-coding gene NKX2-1, but its contribution to lung tumorigenesis is not well understood. In this study we knockdown NKX2-1-AS1 by siRNA transfection and analyze the effect on gene expression in the lung carcinoma H441 cell line.

PubMed ID

30258080

Publication Title

NKX2-1-AS1 negatively regulates CD274/PD-L1, cell-cell interaction genes, and limits human lung carcinoma cell migration.

Total Samples

Submitter’s Institution

Boston University

Authors

Kathuria H, Millien G, McNally L, Gower AC, Tagne JB, Cao Y, Ramirez MI

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-104691

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