Time course of MEK inhibition

GSE10088

Homo sapiens

4 Downloadable Samples

Affymetrix Human Genome U133A 2.0 Array (hgu133a2)

Submitter Supplied Information

Description

This study used microarray expression analysis to identify global changes in transcript alteration in response to MEK inhibition. Genes under ERK control were identified in a representative V600E BRAF cell line as a function of time following exposure to a small molecule inhibitor of MEK.

PubMed ID

19251651

Publication Title

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway.

Total Samples

Submitter’s Institution

Memorial Sloan-Kettering Cancer Center

Authors

Pratilas CA, Taylor BS, Ye Q, Viale A, Sander C, Solit DB, Rosen N

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-10088

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