Expression profiling of V600E BRAF and RTK-activated cells upon MEK inhibition

This study used microarray expression analysis to identify global changes in transcript alteration in response to MEK inhibition. Genes under ERK control were identified in a panel of V600E BRAF and RTK-activated tumor cells and xenografts, using short-term inhibition of ERK activity using the MEK inhibitor PD0325901 (Pfizer).

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Pratilas CA, Taylor BS, Ye Q, Viale A, Sander C, Solit DB, Rosen N