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Accession IconE-MEXP-50

Transcription profiling of human NIH 3T3 inducible cell line to study the role of PKR in regulating gene expression

Organism Icon Mus musculus
Sample Icon 4 Downloadable Samples
Technology Badge Icon Affymetrix Murine 11K SubA Array (mu11ksuba), Affymetrix Murine 11K SubB Array (mu11ksubb)

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PKR is an interferon induced serine/threonine protein kinase, that is activated by double stranded RNA. PKR plays an important role in the antiviral defense by interferon. In addition to its role in translation, PKR participates in several signaling pathways to transcription. The goal of this experiment is to study the role of PKR in regulating gene expression in our NIH 3T3 inducible cell line, which could overexpress PKR wt protein after the removal of tetracycline (Donze O, Dostie J, Sonenberg N. (1999) Virology 256: 322-9).
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