E-MEXP-2071Transcription profiling of rat heart from a spontaneously hypertensive strain treated with doxorubicin or dexrazoxane and then doxorubicin
Rattus norvegicus
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This study was initiated to characterize early DOX-induced changes in cardiac gene expression in order to identify potential additional areas for clinical intervention. Male spontaneously hypertensive rats (SHR) received 3 mg/kg DOX or vehicle (iv) 30 minutes following pretreatment with 50 mg/kg DZR or saline (ip) weekly for 1, 2 or 3 weeks.
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